Tinkering With Backup Processes

I recieved a scare with losing my Immich data (it spawned a new, separate folder with different capitalization and forgot everything. A reset cleared it up) so I'm thinking of actually taking the 1-2-3 backup protocol seriously. I have some OneDrive storage that came with my relative's Microsoft subscription that should be big enough. My current plan is to use Syncthing + Rclone to backup my container data and then save my configs as a private GitHub repo. Syncthing to sync the data between the two laptops I have serving as nodes and Rclone to send the data to Cloud. Simple. After a bit of thought, some doubts started to kick in. A few services like Memos actively operate on the data I'm thinking of syncing. And maybe just running two RClone containers would be easier than running 1 + 2 Syncthing containers. That kind of stuff. So I figured I might as well come here and ask how you guys generally handle backing things up. Any tips?