S&P 500 Futures Decline in Premarket Trading; Definium Therapeutics, Primo Brands Lead

With U.S. stock markets set to open in two hours, Definium Therapeutics Inc. (DFTX) was up 15.7% in pre-market trading, and Primo Brands Corp. (PRMB) was up 10.6%.

Verisk Analytics Inc. (VRSK), RLI Corp. (RLI), and Elastic N.V. (ESTC) were all posting gains of at least 8%. In early trading, Onto Innovation Inc. (ONTO) and Corning Inc. (GLW) had posted declines, falling 8.8% and 8.1%, respectively.

Meanwhile S&P 500 futures were down 0.60%, with futures for the Dow Jones Industrial Average falling 0.20%. The Cboe Volatility Index futures were down 7.20%.

In commodities news, Brent crude oil futures were up 3.34%, and gold futures were down 1.65%. Bitcoin rose 0.75% to $77,833.

The 10-Year Treasury yield held steady at 4.974%.

In the previous regular trading session, the S&P 500 and the Dow were up 0.86% and 0.98%, respectively. Stocks in Asia were down overnight, with Japan’s NIKKEI 225 Index down 0.81% and China’s Shanghai Composite Index falling 0.07%.

In afternoon trading, stocks in Europe are mixed, with the STOXX Europe 600 Index declining 0.20% and the FTSE 100 Index rising 0.63% from the previous close.

U.S. stock markets open for trading at 9:30 a.m. ET. For regular updates on the trading day, visit Barron’s.

Copyright ©2026 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8