Why haven't organoids solved all of drug discovery?

Thank you to Jimmy Sastra and Kitchener D. Wilson for discussions relating to this piece. All opinions are my own.

This essay is the first of three covering organoids. The full set is:

1. Why haven’t organoids solved all of drug discovery?
2. [Unreleased]
3. [Unreleased]

1. What are organoids anyway?
2. Why haven’t organoids solved all of drug discovery?
3. The problems with organoids
   1. The reproducibility of organoid work is (likely) abysmal
   2. Many therapeutic knobs are not exposed in organoids, and it is difficult to add them in
   3. An organoid’s relationship to age is strange
4. Conclusion, and what are organoids good for then?

What are organoids anyway?

If someone placed a gun to the side of your temple and asked you to correctly define what exactly an “organoid” is, or else they’ll shoot, you may get a little nervous.…