Static IP and netplan stop working a couple days after fresh install Ubuntu Server 18.04 LTS

Having some major issues with networking on Ubuntu 18.04 LTS. Fresh install. I set a static IP during install which worked for a couple days and remained set after multiple reboots. Now the interface shows no IP. It seems when I set that IP it did generate a netplan that appears correct however netplan apply does nothing.

This happened to me previously as well on the previous install. I had been messing with some DNS stuff so I figured I'd just reimage the machine and not touch any of the network utilities this time and I still am having the issue.

The issue occurs about a day and a half after install seemingly randomly. Was not using the machine when the issue began and the only thing I have done so far on this install is set up a couple docker containers with samba and SFTP.

Contents of my 50-cloud-init.yaml

Terminal output from netplan --debug apply

My ifconfig